Chromatin vs. Chromatid: What’s The Difference? 7 Facts

How are chromatin and chromatids different from each other? Chromatin is what makes up chromosomes, while chromatids are the two halves of a chromosome that join together when a cell divides. Here, you can find more information.

What Is Chromatin?

“Chromatin” is the name for the mix of protein and DNA that makes up the chromosomes in human and other cells.

Most proteins, like histones, can pack together the large amount of DNA in a genome so that it can fit in the cell nucleus. The DA is about 5 to 6 feet long and can’t fit neatly into the cell’s nucleus.

So, the DNA molecules first wrapped themselves around the histone protein to make nucleosomes, which look like beads on a string. The nucleosomes then stick together to make chromatin, which is a stringy substance.

Chromatin vs. Chromatid

During cell replication and duplication, chromatin gets more compact and looks like chromosomes, which can be seen under a microscope and are split into daughter cells during cell division.

What Is Chromatid?

A chromatid is one of the two identical halves of a chromosome that have been copied so that the cell can divide. At the centromere, a certain part of the chromosome, two sister chromatids are brought together.

During cell division, the spindle fibre, which is attached to the centromere, pulls each sister chromatid to the opposite side.

When cells divide, they make new cells that have the same DNA. This is important for growth and for replacing cells that have been damaged.

For example, if someone gets a cut on their skin, the cut will heal. Because cells can copy each other, the new cells are exact copies of the old ones.

There are also copies of the chromosomes called chromatids. These copies have certain features that make it possible to tell daughter cells apart.

5 Key Differences Between Chromatin and Chromatid

DefinitionChromatin is a protein and nucleic acid complex found in the nucleus of eukaryotic cells, whose main function is to package the long DNA molecules into denser shapes and prevent the tangling of strands.On the other hand, a chromatid is a replicated chromosome with two daughter strands joined by a single centromere. These strands separate during cell division and become a single chromosome.
StructureChromatin contains histones and DNA, in which 147 base pairs of DNA are wrapped around eight core histones.The structure of the sister chromatids remains to change throughout the stages of cell divisions.
FormationDNA molecules wrap around the histone protein and form a bead on a string-like structure called a nucleosome. Nucleosomes further gather to form chromatin.Nucleosomes form chromatin fiber by folding up. Then the loops of this chromatin fiber are compressed and folded to produce 250-nm wide fiber, which is coiled into chromatid.
TypesThere are two main types of chromatin: euchromatin and heterochromatinIntrachromosomal recombination has two types of chromatid interaction: sister chromatid and Intra chromatid
FunctionThe primary function of chromatin is to convert long DNA molecules into a denser and compact structure.Chromatids are important to make sure the daughter cells are healthy and fully functional and carrying a full complement DNA

Chromatin vs. Chromatid Similarities

  • Chromatid and chromatin both contain RNA.
  • Both are very important when it comes to chromosomes and genetic material.

Chromosome vs. Chromatid vs. Chromatin

It may seem like the words chromosome, chromatin, and chromatid are the same, but they are not. All of these words are similar, but they are all made and used in different ways.

Chromosomes are made up of thread-like structures made of nucleic acids and proteins. It is in the neck of the cell and moves genes, which carry genetic information.

Chromatin, on the other hand, is a substance that makes up the chromosomes of humans and many other important species.

It has DNA, RNA, and protein in it. A chromatid is one of the two parts of a chromosome that are the same and are copied when a cell divides.

Chromatin Pros and Cons

Pros of Chromatin

  • Because it allows regulatory agents to access DNA that is packed together, chromatin remodelling is important for controlling gene expression in eukaryotic cells.
  • During mitosis, chromatin also makes it possible for chromosomes to be moved and split up.

Cons of Chromatin

  • Uncontrolled I chromatin can cause health issues such as neurodevelopmental disorders and intellectual disabilities.
  • If the wrong amino acid is in the chromatin protein, the structure can change completely, which makes it less useful.

Chromatin vs. Chromatid

Pros and Cons of Chromatid

Pros of Chromatid

Chromosomes are needed to make sure that daughter cells stay healthy and work right. taking on the DNA of their parents.

Cons of Chromatid

  • If the sister chromatid didn’t split during meiosis II, one gamete would be born without the chromosome.
  • Sister chromatid cohesion defect is a rare disease caused by different numbers of copies of chromosomes in different cells.


Both chromatin and chromatids are important parts of our and other major species’ genes. These two words are related, but they are also very different.

The main difference between chromatin and chromatid is that chromatin is found in the nucleus and is used to wrap long DNA molecules to make them more dense, while chromatid is one of the two identical halves of the chromosome that are made when a cell divides.

Both chromatids and chromatin have different structures and do different things. In the chromatin structure, the DNA is wrapped around the histone protein. However, the shape of the chromatid changes when the cell divides.

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